Table 1.

Summary of B7-H3 expression and MGC018 in vitro cytotoxicity against the indicated human tumor cell lines.

IndicationBreast cancerMelanomaOvarian cancerLung cancerPancreatic cancerGlioblastomaColorectal cancerB-cell lymphoma
Cancer cell lineMDA-MB-468A375.S2PA-1Calu-6NCI-H1703Hs700TLN-229SW48Raji
QFACS (ABC)57,000153,00073,700138,000122,000310,000139,00059,800Negative
MGC018 flow binding EC50 (nmol/L)460456323406354797420253Negative
MGC018 cytotoxicity IC50 (pmol/L)7671812752605853199101447>10,000
  • Abbreviations: ABC, antibody-binding capacity; EC50, half-maximal effective concentration; IC50, half-maximal inhibitory concentration; QFACS, quantitative flow cytometry.