Table 3.

Gastric cancer PDX models.

GC PDX modelHER2 statusRoute/scheduleDose (mg/kg)% TGIP
STO #069HER2 pos (IHC3+/FISH pos)i.v.: QD × 1335<0.05
10100<0.05
STO #041HER2 pos (IHC3+/FISH pos)i.v.: QD × 1343<0.05
1096<0.05
STO #395HER2 pos (IHC3+/FISH pos)i.v.: QD × 1381<0.05
1093<0.05
STO #410HER2 pos (IHC3+/FISH pos)i.v.: QD × 1314ns
1095<0.05
STO #151HER2 pos (IHC2+/FISH pos)i.v.: Q11D × 3197<0.05
3100<0.05
STO #306HER2 pos (IHC3+/FISH pos)i.v.: Q11D × 3186<0.05
399<0.05
STO #286HER2 pos (IHC3+/FISH pos)i.v.: Q11D × 3186<0.05
396<0.05
STO #091HER2 pos (IHC3+/FISH pos)i.v.: Q11D × 3150<0.05
358<0.05
STO #179HER2 low (IHC1+/FISH neg)i.v.: Q11D × 3184<0.05
3100<0.05
STO #053HER2 low (IHC2+/FISH neg)i.v.: Q11D × 3147<0.05
382<0.05
STO #345HER2 low (IHC2+/FISH neg)i.v.: Q11D × 3134<0.05
359<0.05
STO #371HER2 low (IHC2+/FISH neg)i.v.: Q11D × 3125ns
319ns
  • Note: Bold text indicates tumor regression (% TGI >80).

  • Abbreviations: GC, gastric cancer; i.v., intravenous; ns, not significant; QD × 1, every day; Q11D × 3, every 11 days.