Table 2.

Breast cancer PDX models.

BC PDX modelHER2 statusRoute/scheduleDose (mg/kg)%TGIP
BC #046HER2 pos (IHC3+/FISH pos)i.v.: QD × 1184<0.05
399<0.05
BC #013HER2 pos (IHC3+/FISH pos)i.v.: QD × 1185<0.05
392<0.05
BC #197HER2 pos (IHC3+/FISH pos)i.v.: QD × 1166<0.05
391<0.05
BC #128HER2 pos (IHC3+/FISH pos)i.v.: QD × 11−25ns
347<0.05
BC #207HER2 pos (IHC3+/FISH pos)i.v.: QD × 1118ns
320ns
BC #058HER2 pos (IHC3+/FISH neg)i.v.: QD × 1120ns
338ns
BC #239HER2 low (IHC2+/FISH neg)i.v.: QD × 1168<0.05
387<0.05
BC #085HER2 low (IHC2+/FISH neg)i.v.: QD × 1142<0.05
357<0.05
  • Note: Bold text indicates tumor regression (% TGI > 80).

  • Abbreviations: BC, breast cancer; i.v., intravenous; ns, not significant; QD × 1, every day.