Table 1.

Cellular profiling of M3814 in cancer cell lines.

Cellular profiling of M3814
Bleomycin-inducedClonogenicity ± irradiation, IC50 (M)
Cancer cell lineOriginpDNA-PK, IC50 (M)0 Gy2.4 Gy4.8 Gy
MO59JBrainn.d.4 × 10−5No concentration-dependence
MO59KBrain2 × 10−71 × 10−54 × 10−73 × 10−7
HCT-116Colon1 × 10−7>1 × 10−52 × 10−78 × 10−8
HT29Colon1 × 10−72 × 10−54 × 10−72 × 10−7
FaDuHead and neck6 × 10−81 × 10−51 × 10−75 × 10−8
A549Lung2 × 10−71 × 10−51 × 10−75 × 10−8
Calu-6Lung2 × 10−71 × 10−57 × 10−83 × 10−8
EBC-1Lung2 × 10−71 × 10−51 × 10−75 × 10−8
NCI-H460Lung1 × 10−63 × 10−52 × 10−71 × 10−7
BxPC-3Pancreas2 × 10−71 × 10−51 × 10−77 × 10−8
KP-4Pancreas4 × 10−73 × 10−52 × 10−77 × 10−8
MiaPaCaPancreas5 × 10−7>5 × 10−52 × 10−79 × 10−8
DU145Prostate3 × 10−72 × 10−53 × 10−71 × 10−7
  • Abbreviation: DNA-PK, DNA-dependent protein kinase; Gy, Gray unit; IC50, half maximal inhibitory concentration.