Table 1.

Relevant cell line data for oxaliplatin IC50, microdose (micro), and therapeutic dose (thera) induced oxaliplatin–DNA adduct level after 4 and 24 hours, area under the adduct curves (AUC adduct) induced by repair rates in four colorectal cancer cell lines.

DNA Damage:oxaliplatin adducts/108 ntAUC Adducts/108 nt per hour8–24–Hour repair adducts/108 nt per hour
OxaliplatinTheraMicroTheraMicroTheraMicro
Cell lineIC50 (μmol/L)4 Hours24 Hours4 Hours24 Hours
CLL-22810263,1343,05166.1025.67111,114945.11971.39
CLL-22917.814,6518,159129.668.82253,1692,1803022.66
CRL-21340.99,6405,23996.6636.54161,5581,4141732.13
HTB-380.369,95247,821851.8312.11,220,0009,7695236.53