Table 1.

Summary of properties of RITs.

IC50 (ng/mL) in KLM 1Half max mesothelin bindingHalf-life (min)AUCRh
RIT NamesWithout PEGWith PEG (% Activity)(μg/mL)Fast (α)Slow (β)(arbitrary unit, ×104)(nm)
SS1P0.19n/ant19n/antnt
LMB-120.22n/a0.022 ± 0.00111n/a0.23.4
LMB-840.19n/antntn/antnt
LMB-2490.22 ± 0.061.18 ± 0.03 (18%)0.027 ± 0.00114474,4005.97.1
LMB-2030.29 ± 0.021.10 ± 0.19 (26%)0.024 ± 0.0045951,6005.16.9
LMB-1630.22 ± 0.031.13 ± 0.19 (19%)0.029 ± 0.0062962,2844.35.6
LMB-1790.21 ± 0.011.09 ± 0.13 (19%)0.023 ± 0.0023826,6003.95.9
LMB-2440.16 ± 0.030.25 ± 0.05 (64%)0.013 ± 0.001252562.25.2
  • Note: Bolded numbers refer to PEGylated RITs.

  • Abbreviations: n/a, not applicable; nt, not tested.