Table 1.

In vitro cytotoxicity of cabazitaxel dissolved in DMSO and dCTX NPs compared with DTX dissolved in DMSO after 72 hours of incubation (presented as IC50 ± SD in nmol/L)a.

HeLa/DTX cellsA549/DTX cells
DrugsHeLa cellsIC50 (nmol/L)RFbA549 cellsIC50 (nmol/L)RFb
DTX8.3 ± 2.063.5 ± 6.07.72.2 ± 1.4205.2 ± 38.293.3
Cabazitaxel6.5 ± 2.28.5 ± 2.41.31.7 ± 1.114.4 ± 2.18.5
dCTX NPs7.5 ± 1.812.8 ± 3.11.72.2 ± 0.917.7 ± 2.88.0
  • aDetermined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

  • bResistance fold (RF) was determined by dividing IC50 values of HeLa/DTX cells by those of HeLa cells.