Table 2.

Cox proportional hazard model analysis of prognostic factors in patients with breast carcinoma.

VariablesUnfavorable/favorableUnivariateMultivariate
PHR (95% CI)P(95% CI)
Overall survival
 Age (years)≥55/<550.1210.943 (0.875–1.016)
 Tumor size (cm)≥2/2–5/<20.2510.532 (0.181–1.562)
 Lymph node±0.020a2.149 (1.131–4.086)0.3741.718 (0.521–5.666)
 TNM stageI/II/III/IV0.022a2.359 (1.131–4.923)0.8620.884 (0.221–3.538)
 Histologic grade1/2/30.5041.553 (0.427–5.655)
 Molecular subtypesLuminal A/Luminal B/Her2/Base like0.6861.232 (0.448–3.383)
 PDE3A−/+/++/+++0.0871.785 (0.370–8.605)
Disease-free survival
 Age (years)≥55/<550.005a0.922 (1.018–20.26)0.024a0.942 (0.893–0.992)
 Tumor size (cm)≥2/2–5/<20.7261.132 (0.566–2.263)0.7590.901 (0.463–1.754)
 Lymph node±0.019a1.744 (1.097–2.773)0.3071.687 (0.619–4.600)
 TNM stageI/II/III/IV0.003a2.131 (1.283–3.540)0.016a6.014 (1.393–25.96)
 Histologic grade1/2/30.015a3.961 (1.311–16.97)0.5481.933 (0.225–16.57)
 Molecular subtypesLuminal A/Luminal B/Her2/Base like0.3461.675 (0.612–4.060)
 PDE3A−/+/++/+++0.047a4.541 (1.018–20.26)0.043a2.624 (0.492–13.98)
  • aP < 0.05 [χ2 tests; exact significance (two-sided)].