Table 4.

Summary of genotype and outcomes.

CategoryGeneSNP rs id/nucleotideGenotype (N)Number of events (% between allele groups)Median survival, months (95% CI)Pa
DHFRrs11951910TT (25)25 (71.4)5.9 (3.6–6.6)<0.01
T>CTC (10)10 (28.6)2.9 (1.8–3.8)
Progression-GG (13)13 (35.3)3.7 (1.9–5.5)
free survivalrs2838957GA (14)14 (41.2)5.6 (2.3–8.1)0.06
SLC19A1G>AAA (8)8 (23.5)5.1 (1.8–9.7)
GA+AA (22)22 (62.9)5.6 (3.0–7.4)0.02
rs3780130AA (18)18 (51.4)6.8 (5.4–7.2)
A>TAT+TT (17)17 (48.6)11.4 (4.7–19.4)0.01
GGHrs7010484TT (16)16 (45.7)9.2 (6.4–19.4)0.04
T>CTC+CC (19)19 (54.3)6.9 (4.7–10.4)
OverallSLC19A1rs1051266GG (11)11 (31.4)6.7 (2.3–7.4)
survivalGA (16)16 (45.7)8.7 (5.7–22.2)0.03
G>AAA (8)8 (22.9)11.1 (2.6–12.9)
GA+AA (24)24 (68.6)10.1 (6.4–12.9)0.01
  • Note: Content in bold is statistically significant.

  • Abbreviation: N, number of samples with genotype.

  • aLog rank P values.