HPV(+)HPV(–)
PrimaryMetastasisPrimaryMetastasis
# of cases504112442
Age (range)58 (36-81)60 (29-83)64 (25-89)63 (45-89)
Median TMB (range)5.2 (0-18.3)6.1 (0-47.8)3.5 (0-90.5)5.0 (0-13)
PIK3CA GA26%37%17%17%
PTEN GA18%10%2%2%
STK11 GA10%22%1%2%
FBXW7 GA10%10%5%0%
TP53 GA0%5%82%81%
TERTp GA6%10%73%64%
CDKN2A GA0%5%55%52%
CCND1 GA2%2%20%29%
EGFR amp0%0%12%14%
CD274(PD-L1) amp*0%0%6%10%
PD-L1 IHC high*8%11%30%33%
TMB >10*6%24%3%19%