Table 1.

Deubiquitinase enzyme involvement in translational regulation

DUBTranslational machinery substrateRibosome process affectedCancer-associated activityPharmacologic inhibitorDisease reference
USP10G3BPStress granulesAMLHBX19818, P22077(32–35)
RPS125Ribophagy
RPS3RQC
eIF4G1Translation initiation
USP11eIF4BTranslation initiationDLBCLMitoxantrone(40)
FL(100)
USP9XeIF4A1Translation initiationDLBCLWP1130(57)
MM(58)
AML(59)
USP15REST proteinNewly synthesized peptidesLymphomaMitoxantrone(65, 66)
MM(73)
USP21RPS10 (eS10)RQC
OTUD3RPS20 (uS10)RQC
OTUD6BTranslation initiation
eIF3FTranslation inhibition
UCHL-1Translation initiationDLBCL(91)
Lymphoma(95)
MM(96)