Table 2.

IC50 values for the class I PI3K inhibitor BKM120 and the prototypic pan-PI3K inhibitor LY294002 analyzed in three MLS cell lines

IC50 (μmol/L)
CompoundMLS402-91MLS2645-94MLS1765-92
BKM120 (buparlisib)1.46 ± 0.081.01 ± 0.131.84 ± 0.12
LY2940029.57 ± 0.3512.02 ± 1.8611.96 ± 1.72
  • NOTE: Cytotoxic effects on MLS (MLS402-91, MLS2645-94, and MLS1765-92) cell viability were assessed in MTT assays (72 hours). Results are represented as mean ± SEM of at least three independent experiments performed in quintuplicates.