Table 1.

Enriched GO terms in the genome-wide CRISPR-Cas9 screen

ProcessP value
tRNA charging4.13 × 10−23
Cell-cycle control of chromosomal replication4.23 × 10−19
Protein ubiquitination pathway4.29 × 10−19
Estrogen receptor signaling2.47 × 10−17
Assembly of RNA polymerase II complex6.03 × 10−17
Mitotic roles of polo-like kinases8.77 × 10−14
Hereditary breast cancer signaling6.63 × 10−12
Nucleotide excision repair pathway5.74 × 10−11
Purine nucleotides de novo biosynthesis II1.30 × 10−10
Oxidative phosphorylation2.35 × 10−10