Table 1.

Baseline characteristics by SLCO2B1 rs12422149 genotype and response to abiraterone acetate

rs12422149 GG (n = 63)rs12422149 AG (n = 16)rs12422149 AA (n = 0)Pa
log PSA at abiraterone initiation3.22 (1.47)3.60 (1.40)NA0.36
Gleason grade0.35
 42 (3%)00
 5–64 (6%)3 (19%)0
 714 (22%)2 (12%)0
 8–1043 (69%)11 (69%)0
Cox regression results
 Median PFS (months)6.38.9N/A
 Hazard ratio1.00.462 (P = 0.034)N/A
 95% CIN/A0.23–0.94N/A
  • aP values are comparisons across the two observed genotypes.