Table 2.

Baseline characteristics by SLCO2B1 rs1789693 genotype and response to abiraterone acetate

rs1789693 AA (n = 34)rs1789693 AT (n = 38)rs1789693 TT (n = 7)Pa
log PSA at abiraterone initiation2.94 (1.61)3.70 (1.31)2.89 (0.82)0.065
Gleason grade0.37
 40 (0%)2 (5%)0 (0%)
 5–65 (15%)1 (3%)1 (14%)
 75 (15%)9 (24%)2 (28%)
 8–1024 (70%)26 (68%)4 (57%)
Cox regression results
 Median PFS (months)5.656.9313.63
 Hazard ratio1.01.10 (P = 0.75)0.77 (P = 0.59)
 95% CIN/A0.63–1.910.29–2.01
  • aP values are comparisons across the three genotypes.