Table 1.

TSR-033 binding to LAG-3 by surface plasmon resonance (SPR) and LAG-expressing CHO cells

Kinetic parameters (SPR)aLAG-3–expressing CHO cellsb
SpeciesKassoc (milliseconds)−1Kdissoc (seconds)−1KD (nmol/L)EC50 (nmol/L)EC90 (nmol/L)
Human LAG-31.3 × 1051.25 × 10−40.950.811.9
Cynomolgus LAG-31.1 × 1052.3 × 10−42.02.668.5
  • aKassoc, association rate constant; Kdissoc, dissociation rate constant; KD, dissociation constant.

  • bTSR-033 binding not detected on nontransfected CHO cells.