Table 1.

Compounds' potency on recombinant enzymes

TypeEnzyme targetCompoundPrimary enzyme potency (IC50)Secondary enzyme potency (IC50)
Metabolic targetsFASNAZ22139 nmol/L FASN
ACCAZ52202 nmol/L ACC1235 nmol/L ACC2
DGATAZ177 nmol/L DGAT1450 nmol/L ACAT1
PDHKAZ306 nmol/L PDHK237 nmol/L PDHK1
Kinase targetsPanAZ461.2 nmol/L PI3Kα3 nmol/L PI3Kβ
PI3K4 nmol/L PI3Kδ
21 nmol/L PI3Kγ
2 nmol/L mTOR
AKTAZ285 nmol/L AKT142 nmol/L AKT2
21 nmol/L AKT3
mTORAZ644 nmol/L mTOR8.8 μmol/L PI3Kα
5.3 μmol/L PI3Kδ