Table 4.

Comparison of the incidences of ADRs related to candidate SNPs in 129 Chinese patients with GIST

SNP_IDGeneGenotypeNYes (%)No (%)POR95% CI
Edema (n = 65)
rs3814055NR1I2CC4221(50.00)21(50.00)0.2380.5330.187–1.524
CT+TT238(34.78)15(65.22)
Leukopenia (n = 65)
rs1800925IL13CC4422(50.00)22(50.00)0.017a0.2350.068–0.812
CT+TT214(19.05)17(80.95)
rs4073054NR1I3CC4217(40.48)25(59.52)0.9160.9450.334–2.674
CT+TT239(39.13)14(60.87)
rs2307418NR1I3AA6125(40.98)36(59.02)0.9160.480.470–4.884
CC41(25.00)3(75.00)
rs2307424NR1I3CC187(38.89)11(61.11)0.9101.0660.351–3.243
CT+TT4719(40.43)28(59.57)
rs1933437FLT3CC52(40.00)3(60.00)1.0001.0000.155–6.438
CT+TT6024(40.00)36(60.00)
Rash (n = 37)
rs17885098CYP2C19CT51(20.00)4(80.00)0.6302.7370.274–27.354
TT3213(40.63)19(59.38)
rs884225EGFRAA41(25.00)3(75.00)1.0001.9500.183–20.827
AG+GG3313(39.39)20(60.61)
rs28557040EGFRAA3113(41.94)18(58.06)0.3760.2770.029–2.660
AG61(16.67)5(83.33)
rs11543848EGFRGG122(16.67)10(83.33)0.0844.6150.836–25.491
AG+AA2512(48.00)13(52.00)
rs712829EGFRGG3012(40.00)18(60.00)0.6870.6000.100–3.612
TT72(28.57)5(71.43)
rs10228436EGFRGG114(36.36)7(63.64)0.7231.5000.352–6.397
AG+AA2610(38.46)16(61.54)
rs2459693PIK3CACC43(75.00)1(25.00)0.1420.1670.015–1.794
CT+TT3311(33.33)22(66.67)
rs12668095GG3012(40.00)18(60.00)0.6870.6000.100–3.612
GC+CC72(28.57)5(71.43)
rs7716492CXCL14CC173(17.65)14(82.35)0.040a5.7041.239–26.255
CA+AA2011(55.00)9(45.00)
rs4796120CCL5AA188(44.44)10(55.56)0.5080.5770.151–2.207
AG+GG196(31.58)13(68.42)
  • aP < 0.05; the differences of the incidence of ADRs between wild-type and mutate allele carriers are significantly.