Table 3.

The correlation between plasma concentration and ADRs

CminCmax
Adverse reactionRPRP
Hepatic dysfunction0.0610.4950.0430.627
Leukopenia−0.1290.1450.0060.951
Edema0.1800.042a0.2090.017a
Rash0.0100.9140.0290.745
Vomiting0.1740.049a0.2250.010a
Diarrhea0.0750.3960.0240.785
Fatigue0.1790.024a0.2110.016a
  • aP < 0.05; the adverse reaction is significantly related to the plasma concentration.