Table 1.

Combination effect of AZD3514 and olaparib in breast cancer cell lines

Cell lineSubtypeER ExpressionPR ExpressionHER2 ExpressionAR ExpressionAZD3514 IC50 (μmol/L, mean ± SD)Olaparib IC50 (μmol/L, mean ± SD)1:1 Combination IC50 (μmol/L, mean ± SD)Combination index (CI value at ED75)
MCF7Luminal+NormalWeakly positive7.72 ± 0.1>103.64 ± 0.0070.24
T47DLuminal++Normal++8.25 ± 0.101>10>100.63
BT-474HER2+++Amplified++>10>109.822 ± 0.1343.14
MDA-MB-453HER2+Amplified+++8.08 ± 0.544.52 ± 0.0093.1 ± 0.011.46
HCC1143TNBCNormalWeakly positive>10>10>102.25
MDA-MB-468TNBCNormal+>105.8 ± 0.022 ± 0.050.49
MDA-MB-231TNBCNormal+7.3 ± 0.024>103.14 ± 0.0170.39
BT-549TNBCNormal++>10>108.4 ± 0.1555.75
Hs578TTNBCNormal+>10>10>102.78