Table 1.

Levels of biomarkers at baseline and on-treatment

BL (n = 37)C1D8 (n = 29)C2D1 (n = 33)EOS (n = 27)
BiomarkerUnitMedian (range)Median (range)Median (range)Median (range)
Ang-2pg/mL376.6 (201.2–10399.5)309.8 (157.5–1461.6)252.9 (148.9–5721.5)276.5 (0.0–869.2)
BMP-9pg/mL184.8 (30.2–331.8)193.6 (75.5–321.1)182.0 (54.0–272.9)161.3 (39.2–280.4)
CRPμg/mL4.9 (0.2–2003.5)3.1 (0.2–1181.6)6.4 (0.3–1416.4)8.2 (1.3–525.4)
Endoglinng/mL22.0 (11.4–30.4)20.8 (13.5–28.4)99.7 (44.5–177.9)112.4 (37.0–221.8)
E-Cadherinng/mL9.7 (3.6–35.4)8.8 (2.1–44.0)12.3 (5.4–39.4)10.2 (1.9–40.4)
E-Selectinng/mL45.8 (18.1–253.3)43.4 (14.7–299.1)68.7 (34.0–490.5)76.0 (32.6–327.2)
GRO-αpg/mL43.1 (5.5–222.6)42.9 (11.2–175.9)56.1 (13.2–227.2)71.8 (6.2–136.6)
HGFpg/mL773.3 (255.8–6572.5)504.4 (217.7–21410.6)735.8 (267.2–2758.2)607.2 (233.6–4090.1)
ICAM-1ng/mL447.5 (236.6–2867.8)419.1 (189.1–1997.9)442.5 (192.4–2594.2)512.3 (292.9–1198.9)
IGFBP-1ng/mL4.8 (0.3–96.9)7.5 (0.5–61.1)5.7 (0.9–228.7)12.8 (0.4–133.2)
IGFBP-2ng/mL874.9 (116.9–4827.6)879.2 (171.8–2017.2)963.4 (252.6–3700.8)987.6 (466.5–5495.7)
IGFBP-3μg/mL1.2 (0.3–2.9)1.4 (0.6–1.9)1.4 (0.2–2.5)1.4 (0.2–2.1)
IL6pg/mL14.8 (0.9–225.4)16.0 (2.2–440.9)15.9 (1.6–348.4)37.1 (7.9–297.4)
Inhibin Apg/mL35.7 (11.1–73.9)39.6 (23.4–92.0)38.0 (24.3–62.0)36.8 (21.5–63.0)
MCP-1pg/mL357.9 (108.4–6813.2)365.4 (104.7–7388.5)380.9 (118.3–5715.1)447.9 (141.6–3833.2)
MMP-2ng/mL144.5 (52.5–393.0)146.2 (100.2–254.8)153.9 (97.2–312.5)166.4 (117.0–260.0)
MMP-9ng/mL297.1 (98.3–1846.6)213.5 (13.9–1238.2)345.0 (51.4–1932.9)245.4 (87.8–1640.7)
OPNng/mL60.2 (9.6–485.8)62.9 (7.6–127.7)63.8 (10.7–326.3)79.2 (26.4–357.1)
PAI-1 activeng/mL2.8 (0.0–80.7)4.9 (0.0–86.8)5.4 (0.5–95.1)6.9 (1.1–45.2)
PAI-1 totalng/mL8.6 (1.5–68.8)12.4 (2.1–45.2)14.7 (1.9–47.2)15.5 (3.2–105.2)
PDGF-AApg/mL133.4 (9.2–980.1)122.5 (4.0–1939.5)197.5 (6.9–1349.2)231.7 (3.6–1171.9)
PDGF-BBpg/mL156.8 (0.2–1564.6)114.5 (0.4–1918.6)215.4 (0.8–1810.7)225.0 (0.7–1140.0)
PEDFμg/mL1.5 (0.6–3.0)1.4 (0.8–2.7)1.7 (0.2–4.9)1.5 (0.2–2.6)
PIGFpg/mL8.3 (1.2–159.1)13.3 (7.2–33.3)16.0 (3.8–210.8)19.1 (6.0–273.4)
P-Selectinng/mL165.8 (39.2–620.9)158.6 (38.6–609.6)227.4 (28.5–955.5)249.2 (52.3–744.1)
SDF-1ng/mL0.9 (0.3–2.1)0.9 (0.3–3.4)1.5 (0.5–3.2)1.6 (0.2–2.8)
TGFβ1ng/mL37.8 (12.7–171.0)33.5 (11.7–203.9)47.2 (16.0–312.7)53.3 (26.5–279.5)
TGFβ2pg/mL41.8 (11.9–708.7)34.4 (17.9–707.9)42.8 (17.3–447.5)41.3 (20.6–338.2)
TGFβ-R3ng/mL83.6 (28.7–178.3)85.6 (34.8–158.9)100.2 (45.9–177.6)99.9 (31.7–180.6)
TSP-2ng/mL41.5 (17.6–268.4)38.5 (15.6–247.4)39.0 (14.5–193.2)39.6 (14.7–167.2)
VCAM-1μg/mL2.5 (1.2–8.2)2.4 (1.3–7.8)3.6 (1.9–8.2)4.7 (2.5–11.5)
VEGFpg/mL99.8 (15.6–506.0)107.8 (13.5–378.8)124.6 (27.4–329.7)137.5 (20.0–303.4)
VEGF-Dpg/mL812.3 (159.5–1593.5)858.0 (137.8–1689.4)777.8 (93.9–1812.6)971.7 (80.0–1825.0)
VEGF-R1pg/mL63.6 (5.7–1734.0)32.7 (6.2–7205.7)47.7 (5.5–686.3)65.1 (18.7–649.9)
VEGF-R2ng/mL1.5 (0.5–2.5)1.6 (0.7–3.2)1.4 (0.5–2.7)1.2 (0.3–4.0)
vWFU/mL8.6 (1.8–70.8)7.4 (1.2–67.0)10.4 (3.7–32.0)10.2 (3.1–30.1)
  • Abbreviations: Ang-2, angiopoietin-2; BMP-9, bone morphogenetic protein-9; CRP, C-reactive protein; GRO-α, growth-related oncogene-alpha; HGF, hepatocyte growth factor; ICAM-1, intercellular adhesion molecule-1; IGFBP, insulin-like growth factor binding protein; IL6, interleukin 6; MCP-1, monocyte chemotactic protein-1; MMP, matrix metallopeptidase; OPN, osteopontin; PAI-1, plasminogen activator inhibitor-1; PDGF, platelet-derived growth factor; PEDF, pigment epithelium-derived factor; PlGF, placenta growth factor; SDF-1, stromal cell–derived factor-1; TGF, transforming growth factor; TSP-2, thrombospondin-2; VCAM-1, vascular cell adhesion molecule-1; VEGF, vascular endothelial growth factor; VEGF-R1, VEGF receptor-1; vWF, Von Willebrand factor.