Table 1.

Affinity and species cross-reactivity of MEDI3726, as determined by surface plasmon resonance and competitive ELISA

EC50 ng/mL (95% CI; ng/mL)
Human sPSMA17.92 (13.35–24.05)
Cynomolgus monkey sPSMA16.89 (12.45–22.91)
Rat sPSMADoes not compete
Surface plasmon resonance (KD nmol/L ± SD)
Human sPSMA1.67 ± 0.83
Cynomolgus monkey sPSMA3.11 ± 0.19
  • Abbreviations: EC50, half-maximal effective concentration; KD, dissociation constant.