Table 2.

MTD in mice

ConstructDose (mg/kg)ResultWeight loss (%)
αTac-dsFv-M18-PE24(T)184/4 healthy2
244/4 healthy1
284/4 dead
LMB-2 (αTac-scFv-PE38)0.34/4 healthy2
0.354/4 healthy3
0.42/4 healthy2
0.54/4 dead1
  • NOTE: Swiss mice (n = 4) were given a single dose of immunotoxin and monitored for health to establish the MTD.