Table 1.

IMGN779 in vitro cytotoxicity in leukemic cell lines

Cell lineIMGN779 IC50 (pmol/L)CD33 ABC
CMK70054,589
CMK-863919,605
EOL-1149,692
HEL50035,224
HEL92.1.74039,353
HL60s2824,943
KG-1≥1,0006,801
ML-21715,995
MOLM-13844,354
MV4-11517,757
NB440010,493
OCI-AML23013,760
OCI-AML41013,534
OCI-M11055,353
OCI-M2≥1,0003,345
PL-21≥1,00021,153
SKM-1714,033
TF123065,088
TF1-α≥1,00034,703