Mean pharmacokinetic parameters of ABT-165 after single IV bolus administration in monkeys (n = 2 per dose group)
| Dose (mg/kg) | AUC (mg*hr/mL) | Cmax (μg/mL) | Vss (mL/kg) | CL (mL/day/kg) | t1/2 (days) | MRT (days) |
|---|---|---|---|---|---|---|
| 1 | 2.6 | 30.3 | 35.9 | 10.5 | 2.8 | 3.9 |
| 3 | 9.7 | 92.8 | 33.9 | 7.5 | 4.2 | 4.6 |
| 10 | 47.0 | 395.1 | 35.9 | 5.1 | 4.8 | 7.1 |
| 30 | 207.0 | 1344.4 | 27.0 | 3.7 | 5.1 | 7.8 |
NOTE: Units: Dose (mg/kg); Cmax (denotes the first observed concentrations post IV dosing, μg/mL); Vss (volume of distribution at steady state, mL/kg); t1/2 (half life, days; harmonic mean); AUC (area under the curve from 0 to infinity, mg*hr/mL); CL (serum clearance, mL/day/kg); MRT (mean residence time, days).