Table 1.

Mean pharmacokinetic parameters of ABT-165 after single IV bolus administration in monkeys (n = 2 per dose group)

Dose (mg/kg)AUC (mg*hr/mL)Cmax (μg/mL)Vss (mL/kg)CL (mL/day/kg)t1/2 (days)MRT (days)
12.630.335.910.52.83.9
39.792.833.97.54.24.6
1047.0395.135.95.14.87.1
30207.01344.427.03.75.17.8
  • NOTE: Units: Dose (mg/kg); Cmax (denotes the first observed concentrations post IV dosing, μg/mL); Vss (volume of distribution at steady state, mL/kg); t1/2 (half life, days; harmonic mean); AUC (area under the curve from 0 to infinity, mg*hr/mL); CL (serum clearance, mL/day/kg); MRT (mean residence time, days).