Table 1.

Antiproliferative activity of MI130004 in HER2-positive and -negative cell lines

Tumor cell lineHistotypeHER2 statusIC50 (μg/mL)GSD
HCC-1954BreastPositive0.042.1
SK-BR-3BreastPositive0.032.2
BT-474BreastPositive0.731.2
JIMT-1BreastPositive2.381.4
HGC-27GastricPositive0.971.3
A2780OvaryPositive2.001.3
A2780cisOvaryPositive3.441.2
MDA-MB-231BreastNegative>10
MCF-7BreastNegative>10
Hs 746TGastricNegative>10
  • NOTE: Cell lines were classified as HER2 positive or negative according to IHC analysis. Values represent the geometric mean of three or more different experiments, each performed in triplicate.

  • Abbreviations: GSD, geometric standard deviation; IC50, concentration that inhibits cell growth by 50%.