Table 1.

Cytotoxic effects of SKLB-23bb and ACY1215 against various tumor cell lines

IC50 ± SD (nmol/L)
Tumor typeCell lineSKLB-23bbACY1215
ColonHct11638.56 ± 13.056,246 ± 562
HT2971.94 ± 37.414,145 ± 274
LungH46078.25 ± 32.01>10,000
A54975.45 ± 29.95>10,000
OvarianA2780s36.68 ± 13.65>10,000
SKOV340.17 ± 8.704,783 ± 397
BreastMCF-782.81 ± 12.294,541 ± 74
MDA-MB-23166.2 ± 14.834,237 ± 622
MelanomaA37548.30 ± 14.905,472 ± 374
LiverHepG231.32 ± 8.005,658 ± 267
Multiple myelomaMM1S67.40 ± 7.611,334 ± 453
RPMI-822649.80 ± 23.622,521 ± 799
ARD93.44 ± 27.564,497 ± 513
U26686.94 ± 16.321,354 ± 67
B-Cell lymphomaRamos73.86 ± 8.012,624 ± 821
HBL-1121.28 ± 49.91,070 ± 67
Jeko-1115.8 ± 26.74983 ± 45
LeukemiaLAMA-84s83.55 ± 5.082,431 ± 274
K562116.56 ± 18.081,461 ± 128
MV4-1167.64 ± 20.352,531 ± 358
  • NOTE: The time point for analysis was 72 hours. IC50 values were calculated and data were expressed as means ± SDs. At least two independent experiments against each cell line were performed