Table 2.

Cell-cycle analysis of MI130004 in HER2-positive and -negative cell lines

Tumor cell lineHistotypeHER2 status% G2–M untreated% G2–M MI130004
HCC-1954BreastPositive1974
SK-BR-3BreastPositive1146
JIMT-1BreastPositive1435
HGC-27GastricPositive88
A2780OvaryPositive813
MDA-MB-231BreastNegative1415
MCF-7BreastNegative2020
Hs 746TGastricNegative1521
  • NOTE: Cell lines were classified as HER2 positive or negative according to IHC analysis. Values represent the mean of three or more different experiments. “% G2–M” denotes the percentage of cells arrested in G2 or mitosis as detected by flow cytometry in cells either untreated or treated with MI130004 at 0.1 μg/mL.