Table 1.

EZH2 status in various cancers

EZH2 statusAssociated cancer typeReference(s)
EZH2 overexpressionOvarian(13, 30)
Breast(100)
Prostate(101, 102)
Endometrial(103, 104)
Melanoma(105, 106)
Bladder(107)
Lung(108, 109)
Liver(110)
EZH2 mutation (gain of function)Non-Hodgkin lymphoma (Follicular lymphoma and diffuse large B-cell lymphoma)(111)
EZH2 mutation (loss of function)Myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN)(112)
T-cell–acute lymphoblastic leukemia(113)