Table 2.

Oral absorption potential by the Caco-2 assay for EC-70124

Papp (10−6 cm/s)
DirectionRecovery %R1R2AverageEfflux ratio
A-to-B4912.213.612.91.6
B-to-A7219.420.920.2
  • NOTE: Absorption potential classification: Low if (Papp A–B) < 1.0 × 10−6 cm/s; high if (Papp A–B) = 1.0 × 10−6 cm/s; significant Efflux defined as: Efflux ratio = 2.0 and (Papp B–A) = 1.0 × 10−6 cm/s.