Table 3.

Univariate association of EGFR, HER2, HER3 and PD-1, PD-L1, PD-L2

PD-1 positive lymphocytes in tumor
CovariateStatisticsLevel0–1 N = 332–4 N = 57P-valuea
EGFR average overallN (Row %)≤ Median (0.8)17 (39.53)26 (60.47)0.5
N (Row %)> Median (0.8)14 (32.56)29 (67.44)
HER2 average overallN (Row %)023 (33.82)45 (66.18)0.505
N (Row %)0.025–0.38 (42.11)11 (57.89)
HER3 average overallN (Row %)≤Median (0.1625)19 (44.19)24 (55.81)0.116
N (Row %)>Median (0.1625)12 (27.91)31 (72.09)
PD-1 positive lymphocytes in peritumoral stroma
CovariateStatisticsLevel0–1 N = 112–4 N = 79P-valuea
EGFR average overallN (Row %)≤ Median (0.8)6 (13.95)37 (86.05)0.747
N (Row %)> Median (0.8)5 (11.63)38 (88.37)
HER2 average overallN (Row %)08 (11.76)60 (88.24)0.699
N (Row %)0.025–0.33 (15.79)16 (84.21)
HER3 average overallN (Row %)≤Median (0.1625)6 (13.95)37 (86.05)0.747
N (Row %)>Median (0.1625)5 (11.63)38 (88.37)
PD-L1
CovariateStatisticsLevel0 N = 691–130 N = 23P-valuea
EGFR average overallN (Row %)≤ Median (0.8)38 (84.44)7 (15.56)0.061
N (Row %)> Median (0.8)29 (67.44)14 (32.56)
HER2 average overallN (Row %)051 (73.91)18 (26.09)0.770
N (Row %)0.025–0.316 (80)4 (20)
HER3 average overallN (Row %)≤Median (0.1625)34 (77.27)10 (22.73)0.622
N (Row %)>Median (0.1625)32 (72.73)12 (27.27)
PD-L2
CovariateStatisticsLevel0 N = 311–130 N = 51P-valuea
EGFR average overallN (Row %)≤ Median (0.8)15 (41.67)21 (58.33)0.686
N (Row %)> Median (0.8)16 (37.21)27 (62.79)
HER2 average overallN (Row %)022 (36.07)39 (63.93)0.520
N (Row %)0.025–0.38 (44.44)10 (55.56)
HER3 average overallN (Row %)≤Median (0.1625)13 (36.11)23 (63.89)0.755
N (Row %)>Median (0.1625)17 (39.53)26 (60.47)
  • aThe P-value is calculated by chi-square test or Fisher's exact, where appropriate.