Table 1.

Binding and potency EC50 values (pmol/L) of AU-011 on a panel of human tumor cell lines

BindingKilling
92.1MEL27.37 ± 1.38561.74 ± 2.142
NCI-H460133.7 ± 50.9470.32 ± 28.25
HeLa26.17 ± 3.13766.24 ± 2.708
HSC-310.99 ± 1.11524.72 ± 0.918
MCF-753.28 ± 6.51937.21 ± 4.58
SK-MEL-211.74 ± 0.95625.24 ± 1.693
SK-OV-323.2 ± 1.41437.86 ± 6.831
T2441.12 ± 5.14260.1 ± 18.53
  • NOTE: Values represent mean pmol/L ± SEM, obtained from three experiments performed in triplicate.