Table 2.

Relative frequency of BRAF mutations by tumor type and frequency of mutation (adapted from Flaherty and McArthur [Cancer 2010]) (15)

Tumor typePatients with BRAF mutation, %
Melanoma30–70
Papillary thyroid cancer40–70
Cisplatin-refractory testicular cancer25
Cholangiocarcinoma10–20
Colorectal cancer5–20
Ovarian cancer5–10
Prostate cancer5–10
Glioblastoma, NSCLC, HNSCC, breast cancer, and pancreatic cancer1–5
BRAF mutationPercentage of all BRAF mutations
V600E97.3
V600K1
K601Ea0.4
G469Aa0.4
D594Ga0.3
V600R0.3
L597Va0.2
  • aMost common amino acid change reported at these positions; percentage provided includes all amino acid changes reported for the position.