Table 2.

PDX models of CCA retain the KRAS sequence in codon 12 of the primary tumors from which they were derived

Specimen IDKRAS codon 12 sequence change (F0)Mutation conserved in PDX (F1)Amino acid substitution
CCA1GGTYesWT
CCA2GGT → GATYesG12D
CCA3GGT → GATYesG12D
CCA4GGT → GTTYesG12V
CCA5GGTYesWT
  • NOTE: The sequence of codon 12 of the KRAS gene was determined for F0 and F1 tumors.