Table 1.

Ex vivo biodistribution of 177Lu-DTPA-rituximab and of 177Lu-DTPA-sdAb 9079 coinfused with 150 mg/kg gelofusin in the hCD20pos B16 mouse tumor model (n = 3)

1.5 h6 h24 h48 h72 h120 h
177Lu-DTPA-sdAb 9079
Thymus0.11 ± 0.040.04 ± 0.000.05 ± 0.020.02 ± 0.010.06 ± 0.09NA
Heart0.16 v 0.040.07 ± 0.000.02 ± 0.000.01 ± 0.000.01 ± 0.00NA
Lungs0.34 ± 0.010.14 ± 0.000.03 ± 0.010.02 ± 0.010.01 ± 0.00NA
Liver0.28 ± 0.000.22 ± 0.060.09 ± 0.010.05 ± 0.010.04 ± 0.00NA
Spleen0.20 ± 0.050.09 ± 0.010.10 ± 0.010.04 ± 0.010.03 ± 0.01NA
Pancreas0.13 ± 0.020.08 ± 0.020.02 ± 0.000.01 ± 0.000.01 ± 0.00NA
Kidneys8.58 ± 1.056.33 ± 1.531.47 ± 0.460.38 ± 0.080.22 ± 0.05NA
Stomach0.4 ± 0.240.30 ± 0.290.08 ± 0.100.01 ± 0.000.01 ± 0.00NA
Small intestine0.35 ± 0.060.49 ± 0.110.07 ± 0.020.01 ± 0.000.01 ± 0.01NA
Large intestine0.26 ± 0.100.51 ± 0.150.10 ± 0.100.02 ± 0.010.04 ± 0.01NA
Muscle0.11 ± 0.030.05 ± 0.030.01 ± 0.010.00 ± 0.000.00 ± 0.00NA
Bone0.09 ± 0.010.07 ± 0.000.03 ± 0.010.03 ± 0.000.03 ± 0.00NA
Lymph nodes0.22 ± 0.020.11 ± 0.020.06 ± 0.010.02 ± 0.010.05 ± 0.02NA
Blood0.26 ± 0.050.06 ± 0.040.01 ± 0.000.00 ± 0.000.00 ± 0.00NA
Tumor3.44 ± 1.311.63 ± 0.070.86 ± 0.130.54 ± 0.070.35 ± 0.04NA
1.5 h6 h24 h48 h72 h120 h
177Lu-DTPA-rituximab
Thymus16.3 ± 4.8013.6 ± 1.516.5 ± 0.327.9 ± 0.438.1 ± 0.818.4 ± 0.86
Heart22.9 ± 0.9922.4 ± 7.3711.5 ± 3.8910.6 ± 0.996.1 ± 2.159.6 ± 1.84
Lungs29.1 ± 5.3921.1 ± 1.8212.3 ± 0.8910.7 ± 1.0816.2 ± 2.9113.9 ± 1.70
Liver25.4 ± 2.1720.8 ± 0.5112.5 ± 0.2412.1 ± 1.1111.2 ± 1.5412.4 ± 0.87
Spleen22.8 ± 3.0920.2 ± 0.3315.7 ± 1.8817.9 ± 2.6915.7 ± 2.0112.4 ± 7.20
Pancreas9.6 ± 3.246.2 ± 1.204.7 ± 0.544.2 ± 0.694.8 ± 0.363.7 ± 0.60
Kidneys28.3 ± 3.7118.9 ± 1.9412.7 ± 0.2810.8 ± 1.2411.9 ± 0.8514.5 ± 0.33
Stomach5.1 ± 1.393.7 ± 0.902.8 ± 0.482.8 ± 0.882.3 ± 0.542.1 ± 0.38
Small intestine7.4 ± 1.305.8 ± 0.906.1 ± 4.796.8 ± 5.812.6 ± 0.532.8 ± 0.42
Large intestine2.8 ± 2.185.7 ± 1.013.5 ± 0.995.7 ± 4.872.2 ± 0.222.8 ± 0.48
Muscle3.0 ± 1.243.5 ± 0.382.9 ± 0.202.9 ± 0.382.6 ± 0.363.9 ± 0.61
Bone9.1 ± 3.2317.2 ± 1.3715.2 ± 2.0133.5 ± 10.248.8 ± 14.9077.4 ± 14.93
Lymph nodes4.4 ± 4.5812.4 ± 0.1010.7 ± 2.5611.6 ± 1.9211.5 ± 6.2716.4 ± 1.74
Blood98.1 ± 13.371.0 ± 1.4937.2 ± 2.5734.3 ± 3.5229.7 ± 6.0535.1 ± 5.18
Tumor10.7 ± 1.8619.9 ± 5.2723.5 ± 3.3721.9 ± 1.8117.8 ± 2.9527.4 ± 5.40
  • NOTE: Results are presented as mean % IA/g ± SD.