Table 1.

Summary of enriched pathways associated with 53BP1 response

Reactome pathway (major, minor)Pathway proteinsGene set proteinsPFDRHit genes
Cell cycle500401.11E−161.47E−14
 Cell-cycle checkpoints149181.98E−129.52E−11RFC4, PSMA6, RFC2, MRE11A, ANAPC10, CHEK1, RNF168, BRCA1, NBN, TP53, MCM2, MCM3, MCM5, MCM6, SUMO1, PSMD14, PSMD12, BARD1
 Cell cycle, mitotic399259.39E−112.44E−09KNTC1, ESCO2, RFC4, PSMA6, RFC2, ZWINT, ANAPC10, POLE2, GINS2, GINS3, GINS4, DHFR, PCNA, SEH1L, PRKCA, MCM2, MCM3, MCM5, MCM6, RRM2, TYMS, BUB1, FEN1, PSMD14, PSMD12
 Chromosome maintenance6462.56E−042.44E−03RFC4, RFC2, POLE2, PCNA, FEN1, TERF1
 Meiosis63101.80E−083.75E−07RAD51C, MND1, BLM, MRE11A, BRCA1, NBN, PSMC3IP, RAD51, TOP3A, TERF1
DNA repair258321.11E−161.47E−14
 Base excision repair3181.30E−082.86E−07LIG3, POLB, RFC4, RFC2, TDG, PCNA, UNG, FEN1
 DNA damage bypass4443.18E−030.0191USP1, RFC4, RFC2, PCNA
 DNA double-strand break repair4472.68E−064.29E−05MRE11A, RNF168, BRCA1, NBN, TP53, SUMO1, BARD1
 Nucleotide excision repair10288.15E−058.66E−04LIG3, RFC4, RFC2, PCNA, INO80D, XPA, POLR2D, SUMO1
 Mismatch repair1531.18E−038.62E−03PCNA, EXO1, MSH2
 Fanconi anemia pathway3630.01330.0624USP1, FANCE, FANCC
Programmed cell death15460.01890.0756MLKL, PSMA6, TP53, DAPK1, PSMD14, PSMD12