Table 2.

Statistical analysis of the effect of treatment with RO4987655 on metabolites identified preclinically in patient with PD and partial response (PR)

PDPR
Kruskal–WallisDunn's multiple comparison testKruskal–WallisDunn's multiple comparison test
C1-8hC1-24hC2-preC2-8hC2-24hC1-8hC1-24hC2-preC2-8hC2-24h
MetabolitesP valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P valueP valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P value
C30.229429.420.150527.580.1348140.353711.86>0.999914.170.69010.632443.13>0.9999300.457229>0.999923>0.999978.2>0.9999
Arg0.004350.330.002241.080.049935.380.110657.860.004839.170.04890.242822.630.263313.88>0.99995.571>0.999921.57>0.9999310.3115
Asn<0.000147.67<0.000121.250.023343.130.000362.710.000427.670.04760.101215.750.765615.130.737321.430.223524.860.6127470.0185
Ile0.000669.080.000431.750.209124.25>0.999980.430.001642.50.21670.053543.750.069933.380.03716.714>0.999923.14>0.999930.20.0826
Leu<0.000160.58<0.000124.670.207324.50.172771.290.000337.50.06350.0879320.075921.50.13285.286>0.999914.43>0.999922.80.0997
Phe0.0007410.000813.920.492924.750.04853.140.000828.170.12140.751210.75>0.99996.5>0.99992>0.99991>0.999919.2>0.9999
Trp0.053936.830.014213.33>0.9999210.19526.71>0.99995.167>0.99990.029112>0.999914.75>0.9999−15.570.6823−31.140.1187−1.8>0.9999
Tyr0.000356.750.000331.750.075938.880.012463.290.000438.670.03750.277120>0.999917.63>0.999910.29>0.99993.286>0.999928.40.6478
Val0.011826.250.001311.080.242113.130.282726.570.047510.670.37230.14810.50.83713.380.06374>0.9999−0.7143>0.9999110.5475
Met-SO0.063380.67230.140.944834.75>0.9999116.70.0204113.50.16240.9454240.6>0.9999226.4>0.9999833.8>0.9999125>0.999956.25>0.9999
PC aa C30:00.056619.250.29357.833>0.999942.380.1132460.21315>0.99990.5601−5.875>0.9999−5.375>0.99996>0.9999−16.71>0.9999−11.4>0.9999
PC aa C38:60.065713.920.56869.75>0.99994>0.999917.86>0.9999−18.50.44090.0243−2.75>0.99995.75>0.9999−17>0.9999−34.860.1757−280.4232
PC aa C40:10.51026.583>0.99996.167>0.99998.250.80578.143>0.99990>0.99990.02348.375>0.999913.13>0.9999−200.5132−21.570.3441−16.40.7246
PC ae C42:00.59517.8330.40556.667>0.99997.750.83419.286>0.9999-1>0.99990.51544.625>0.99999.25>0.99998.429>0.9999−11.57>0.9999−2.8>0.9999
PC ae C42:40.373811.250.24564.25>0.999918.38>0.999919.710.64194.667>0.99990.0052−6.5>0.99990.875>0.9999−15.430.3501−34.430.0038−20.20.3293
PC ae C44:30.73926.5>0.99994.917>0.999922.75>0.999920.29>0.99997.5>0.99990.129612.25>0.999924.750.547719.29>0.9999−11>0.9999−9>0.9999
PC ae C44:60.51768.167>0.99991.25>0.999913>0.999920.290.77782.833>0.99990.0166−10.75>0.9999−3.5>0.9999−13.570.8398−32.570.0074−22.20.1035
SM C16:00.050712.25>0.99997.25>0.9999−3.750.59320.28570.9647−14.330.23280.0066−4.75>0.99991.75>0.9999−11.570.4553−24.290.0415−20.80.0531
SM C20:20.326416.17>0.999910>0.9999−7.875>0.99996>0.9999−11.33>0.99990.00140>0.99997.875>0.9999−16.140.0913−24.860.0344−25.20.0148
SM C24:10.156212.750.50768.25>0.9999−5.5>0.99990.1429>0.9999−11.67>0.99990.0739−7.5>0.99992.5>0.9999−5.143>0.9999−19.290.275−17.20.1544
SM C26:10.07968.9170.95146>0.9999−4.75>0.9999−4.714>0.9999−16.670.42240.0986−6>0.99998>0.9999−7.286>0.9999−22.140.3339−19.60.7613
  • NOTE: Statistical tests carried out are Kruskal–Wallis test for all time points and Dunn's multiple comparison tests for individual time points (P values <0.05 are bold). Mean values are percentage increase or decrease relative to time 0.