Table 3.

Relationship between baseline candidate biomarker levels with objective response and presence of tumor BRAF mutation (P values <0.05 are bolds)

Mann–Whitney testPatient comparisonROC analysis PD vs. PRMann–Whitney test+/− BRAF mutation
P valueMedian of PD (μM)Median of PR (μM)AUC95% confidence intervalP valueP valueMedian of mutated (μM)Median of non mutated (μM)
Metabolites
C30.62390.2585, n = 120.2396, n = 80.57290.3121–0.83370.58920.31140.2737, n = 70.2520, n = 13
Arg0.009664.51, n = 1287.93, n = 80.84380.6646–1.0230.0109>0.999971.06, n = 772.84, n = 13
Asn0.678443.60, n = 1243.44, n = 80.56250.3029–0.82210.64340.182744.92, n = 741.54, n = 13
Ile0.571459.99, n = 1255.37, n = 80.58330.3146–0.85210.53710.311459.88, n = 750.85, n = 13
Leu0.5208107.6, n = 12101.5, n = 80.59380.3186–0.86890.48750.2414102.6, n = 797.70, n = 13
Phe0.097960.29, n = 1267.46, n = 80.72920.5073–0.95100.08960.014575.23, n = 758.57, n = 13
Trp0.23851.96, n = 1261.09, n = 80.66670.4182–0.91510.2170.58861.58, n = 756.64, n = 13
Tyr0.031451.91, n = 1266.46, n = 80.79170.5862–0.99720.03080.535666.20, n = 754.96, n = 13
Val>0.9999189.0, n = 12178.6, n = 80.50.2272–0.772810.6992185.7, n = 7187.2, n = 13
Met-SO0.38290.5386, n = 70.2994, n = 70.65310.3293–0.97680.33790.14690.2836, n = 50.5988, n = 9
PC aa C30:00.13492.829, n = 123.952, n = 80.70830.4611–0.95560.12280.75733.799, n = 72.895, n = 13
PC aa C38:60.005558.20, n = 12115.5, n = 80.86460.6647–1.0650.00690.588100.2, n = 765.83, n = 13
PC aa C40:10.01590.3345, n = 120.4752, n = 80.82290.6194–1.0260.01680.93850.3673, n = 70.3495, n = 13
PC ae C42:00.01240.4863, n = 120.7681, n = 80.83330.6543–1.0120.01360.11460.7605, n = 70.5126, n = 13
PC ae C42:40.15690.6470, n = 120.7494, n = 80.69790.4640–0.93180.14270.75730.6656, n = 70.7221, n = 13
PC ae C44:30.00960.1298, n = 120.1833, n = 80.84380.6645–1.0230.01090.15740.1776, n = 70.1391, n = 13
PC ae C44:60.13490.7642, n = 121.056, n = 80.70830.4555–0.96110.12280.27490.6329, n = 70.8804, n = 13
SM C16:00.1349185.9, n = 12203.0, n = 80.70830.4779–0.93880.12280.1348197.7, n = 7190.1, n = 13
SM C20:20.02010.7086, n = 121.007, n = 80.81250.6207–1.0040.02060.00850.9905, n = 70.7045, n = 13
SM C24:10.1569212.1, n = 12239.0, n = 80.69790.4586–0.93720.14270.2106234.1, n = 7216.7, n = 13
SM C26:10.20830.7365, n = 120.8440, n = 80.67710.4319–0.92230.18970.01110.8771, n = 70.7203, n = 13