Mann–Whitney test | Patient comparison | ROC analysis PD vs. PR | Mann–Whitney test | +/− BRAF mutation | |||||
---|---|---|---|---|---|---|---|---|---|

P value | Median of PD (μM) | Median of PR (μM) | AUC | 95% confidence interval | P value | P value | Median of mutated (μM) | Median of non mutated (μM) | |

Metabolites | |||||||||

C3 | 0.6239 | 0.2585, n = 12 | 0.2396, n = 8 | 0.5729 | 0.3121–0.8337 | 0.5892 | 0.3114 | 0.2737, n = 7 | 0.2520, n = 13 |

Arg | 0.0096 | 64.51, n = 12 | 87.93, n = 8 | 0.8438 | 0.6646–1.023 | 0.0109 | >0.9999 | 71.06, n = 7 | 72.84, n = 13 |

Asn | 0.6784 | 43.60, n = 12 | 43.44, n = 8 | 0.5625 | 0.3029–0.8221 | 0.6434 | 0.1827 | 44.92, n = 7 | 41.54, n = 13 |

Ile | 0.5714 | 59.99, n = 12 | 55.37, n = 8 | 0.5833 | 0.3146–0.8521 | 0.5371 | 0.3114 | 59.88, n = 7 | 50.85, n = 13 |

Leu | 0.5208 | 107.6, n = 12 | 101.5, n = 8 | 0.5938 | 0.3186–0.8689 | 0.4875 | 0.2414 | 102.6, n = 7 | 97.70, n = 13 |

Phe | 0.0979 | 60.29, n = 12 | 67.46, n = 8 | 0.7292 | 0.5073–0.9510 | 0.0896 | 0.0145 | 75.23, n = 7 | 58.57, n = 13 |

Trp | 0.238 | 51.96, n = 12 | 61.09, n = 8 | 0.6667 | 0.4182–0.9151 | 0.217 | 0.588 | 61.58, n = 7 | 56.64, n = 13 |

Tyr | 0.0314 | 51.91, n = 12 | 66.46, n = 8 | 0.7917 | 0.5862–0.9972 | 0.0308 | 0.5356 | 66.20, n = 7 | 54.96, n = 13 |

Val | >0.9999 | 189.0, n = 12 | 178.6, n = 8 | 0.5 | 0.2272–0.7728 | 1 | 0.6992 | 185.7, n = 7 | 187.2, n = 13 |

Met-SO | 0.3829 | 0.5386, n = 7 | 0.2994, n = 7 | 0.6531 | 0.3293–0.9768 | 0.3379 | 0.1469 | 0.2836, n = 5 | 0.5988, n = 9 |

PC aa C30:0 | 0.1349 | 2.829, n = 12 | 3.952, n = 8 | 0.7083 | 0.4611–0.9556 | 0.1228 | 0.7573 | 3.799, n = 7 | 2.895, n = 13 |

PC aa C38:6 | 0.0055 | 58.20, n = 12 | 115.5, n = 8 | 0.8646 | 0.6647–1.065 | 0.0069 | 0.588 | 100.2, n = 7 | 65.83, n = 13 |

PC aa C40:1 | 0.0159 | 0.3345, n = 12 | 0.4752, n = 8 | 0.8229 | 0.6194–1.026 | 0.0168 | 0.9385 | 0.3673, n = 7 | 0.3495, n = 13 |

PC ae C42:0 | 0.0124 | 0.4863, n = 12 | 0.7681, n = 8 | 0.8333 | 0.6543–1.012 | 0.0136 | 0.1146 | 0.7605, n = 7 | 0.5126, n = 13 |

PC ae C42:4 | 0.1569 | 0.6470, n = 12 | 0.7494, n = 8 | 0.6979 | 0.4640–0.9318 | 0.1427 | 0.7573 | 0.6656, n = 7 | 0.7221, n = 13 |

PC ae C44:3 | 0.0096 | 0.1298, n = 12 | 0.1833, n = 8 | 0.8438 | 0.6645–1.023 | 0.0109 | 0.1574 | 0.1776, n = 7 | 0.1391, n = 13 |

PC ae C44:6 | 0.1349 | 0.7642, n = 12 | 1.056, n = 8 | 0.7083 | 0.4555–0.9611 | 0.1228 | 0.2749 | 0.6329, n = 7 | 0.8804, n = 13 |

SM C16:0 | 0.1349 | 185.9, n = 12 | 203.0, n = 8 | 0.7083 | 0.4779–0.9388 | 0.1228 | 0.1348 | 197.7, n = 7 | 190.1, n = 13 |

SM C20:2 | 0.0201 | 0.7086, n = 12 | 1.007, n = 8 | 0.8125 | 0.6207–1.004 | 0.0206 | 0.0085 | 0.9905, n = 7 | 0.7045, n = 13 |

SM C24:1 | 0.1569 | 212.1, n = 12 | 239.0, n = 8 | 0.6979 | 0.4586–0.9372 | 0.1427 | 0.2106 | 234.1, n = 7 | 216.7, n = 13 |

SM C26:1 | 0.2083 | 0.7365, n = 12 | 0.8440, n = 8 | 0.6771 | 0.4319–0.9223 | 0.1897 | 0.0111 | 0.8771, n = 7 | 0.7203, n = 13 |