Table 1.

Evaluation of the significance of the changes in metabolite levels compared with predose levels following treatment with the MEK inhibitor RO4987655

Dunn's multiple comparison test
Kruskal–WallisC1-8hC1-24hC2-preC2-8hC2-24h
P valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P valueMeanAdj. P value
Metabolites
C30.001628.460.009934.470.000424.830.008924.80.184743.530.0378
Arg<0.000142.23<0.000126.880.003624.540.003535.750.002435.270.0001
Asn<0.000134.09<0.000120.310.000828.25<0.000147.25<0.000135.67<0.0001
Ile<0.000159.14<0.000131.880.0001150.332647.950.000334.130.0021
Leu<0.000147.26<0.000126.16<0.000114.790.010136.70.000126.670.0002
Phe<0.000128.74<0.000113.470.019819.790.005127.750.002725.930.0022
Trp0.037122.570.107315.940.15265.333>0.9999−0.55>0.99993.733>0.9999
Tyr0.000336.40.000427.560.003628.920.021635.50.004933.60.0015
Val0.000416.49<0.000113.410.00128.3750.084711.90.041711.070.0206
Met-SO0.0046117.80.0348110.20.7205355.70.4795162.80.0286209.90.0034
PC aa C30:00.22720.6286>0.99992.156>0.999925.170.447210.55>0.9999−1>0.9999
PC aa C38:60.00054.286>0.99994.844>0.9999−4.4170.3513−9.10.0409−16.670.0068
PC aa C40:10.21893.8>0.99996.75>0.9999−0.9167>0.9999−5.90.7959−0.5333>0.9999
PC ae C42:00.6262.514>0.99995.094>0.99993.083>0.9999−3.45>0.99991.467>0.9999
PC ae C42:40.65580>0.99992.531>0.99999.417>0.9999−50.4166.267>0.9999
PC ae C44:30.71124.771>0.999910.78>0.999915.17>0.99993.9>0.99999.533>0.9999
PC ae C44:60.6457−0.8286>0.9999−1.594>0.99996.542>0.9999−4.20.91830.1333>0.9999
SM C16:00.00191.686>0.99992.719>0.9999−1.2920.297−11.850.006−11.60.0093
SM C20:20.03173.886>0.99996.781>0.9999−1.250.8285−10.20.0484−9.8670.0728
SM C24:10.12131>0.99993.344>0.99990.875>0.9999−10.10.1824−8.6670.2434
SM C26:10.0096−1.057>0.99992.688>0.99990.375>0.9999−13.550.0303−130.0591
  • NOTE: Statistical tests carried out are Kruskal–Wallis test for all time points and Dunn's multiple comparison tests for individual time points (P values <0.05 are bold). Mean values are percentage increase or decrease relative to time 0.