Table 2.

NP characteristics for each optimized drug-NP formulation

Characteristics for each optimized nanoparticle formulation
Candidate MoleculeNP diam (nmol/L)NP zeta (surface) potential (mV)Drug-NP encapsulation (nmol drug/mg NP)Encapsulation efficiency (%)aRelease during burst phase (%)Duration of linear phase (d)Release Rate during linear phase (nmol/d/mg NP)Release Rate during linear phase (%)
NU744180 ± 3−4 ± 1110 ± 1021 ± 933 ± 341.00.91
KU6064882 ± 2−6 ± 3240 ± 1044 ± 631 ± 152.63.4
BEZ23581 ± 5−3 ± 21.8 ± 0.14.2 ± 2.030 ± 3>140.0110.60
KU6001978 ± 3−5 ± 2320 ± 1045 ± 845 ± 5>143.91.0
VE82265 ± 3−9 ± 4180 ± 1049 ± 436 ± 2>141.40.80
AZD776276 ± 5−5 ± 1640 ± 1052 ± 131 ± 1000
Unloaded (blank)62 ± 3−2 ± 1n/an/an/an/an/an/a
DiD (dye)66 ± 4−7 ± 10.2% by weight100∼0n/an/an/a
  • aDrug loaded/theoretical drug encapsulated.