Table 1.

Relative tumor volume compared with baseline in DDLPS and SynSa patient-derived xenograft models at the end of the efficacy experiment (day 7) and after the regrowth experiment (day 21)

Relative tumor volume (%)
Efficacy experiment (day 7)Regrowth experiment (day 21)
Xenograft modelControlDoxoALGP-doxoControlDoxoALGP-doxo
UZLX-STS3144 ± 36130 ± 41103 ± 27**,#258 ± 113246 ± 74105 ± 20***
UZLX-STS5149 ± 32187 ± 48*132 ± 35##366 ± 153246 ± 193119 ± 35***
UZLX-STS7158 ± 36152 ± 3960 ± 18###479 ± 54361 ± 1715 ± 3*,##
  • Data are presented as average ± standard deviation. Statistical significance was calculated using Mann–Whitney U test

  • *P < 0.05 compared with control.

  • #P < 0.05 compared with doxorubicin.

  • **P < 0.005 compared with control.

  • ##P < 0.005 compared with doxorubicin.

  • ***P < 0.005 compared with control and doxorubicin.

  • ###P < 0.0005 compared with control and doxorubicin.