Table 1B.

AZD6738 sensitizes gastric cancer cells to an anti-microtubule agent

Cell lineAZD6738 IC50 (μmol/L, mean ± SD)Paclitaxel IC50 (μmol/L, mean ± SD)100:1 Combination IC50 (μmol/L, mean ± SD)CI (ED50)
SNU-10.73>0.010.12 ± 0.008<1
SNU-5>10.0050.63 ± 0.1>1
SNU-160.80.0029 ± 0.00070.2 ± 0.03>1
SNU-216>1>0.01>1>1
SNU-484>10.0022 ± 0.00010.34 ± 0.08>1
SNU-6010.38 ± 0.020.004 ± 0.0010.14 ± 0.006<1
SNU-620>10.005 ± 0.00130.4 ± 0.1>1
SNU-6380.35 ± 0.0190.002 ± 0.00020.18 ± 0.005>1
SNU-6680.83 ± 0.028>0.010.6>1
SNU-719>1>0.010.5 ± 0.02<1
AGS0.750.004 ± 0.00050.21 ± 0.014<1
KATO-30.65 ± 0.020.004 ± 0.00280.31 ± 0.01>1
MKN-45>1>0.01>1>1
NCI-N870.47 ± 0.050.007 ± 0.0050.3 ± 0.04>1