Table 1A.

AZD6738 sensitizes gastric cancer cells to a DNA-damaging agent

Cell lineAZD6738 IC50 (μmol/L, mean ± SD)Cisplatin IC50 (μmol/L, mean ± SD)1:10 Combination IC50 (μmol/L, mean ± SD)CI (ED50)
SNU-10.732.01 ± 0.030.2 ± 0.003>1
SNU-5>11.83 ± 0.050.19 ± 0.01>1
SNU-160.82.21 ± 0.120.17 ± 0.01>1
SNU-216>14.05 ± 0.480.37 ± 0.1>1
SNU-484>10.83 ± 0.000010.06 ± 0.0007>1
SNU-6010.38 ± 0.030.59 ± 0.0040.02 ± 0.00001>1
SNU-620>12.75 ± 0.020.211 ± 0.005>1
SNU-6380.35 ± 0.0212.75 ± 0.070.13 ± 0.002>1
SNU-6680.83 ± 0.02>100.32 ± 0.03<1
SNU-719>1>100.18 ± 0.003<1
AGS0.751.46 ± 0.020.16 ± 0.004>1
KATO-30.65 ± 0.022.07 ± 0.030.19 ± 0.007<1
MKN-45>1>100.39 ± 0.3<1
NCI-N870.47 ± 0.051.33 ± 0.0060.063 ± 0.0002<1