Table 1.

In vivo dosing schedules for prexasertib (P) + C225 + IR

MondayTuesdayWednesdayThursdayFriday
ScheduleAMPMAMPMAMPMAMPMAMPM
1C225–IRPPPPP–IRP
2P+C225–IRPP–IRP
3C225–IRPPIRPP
4P+C225–IRPPPP–IRPPP