Table 1.

Genetic backgrounds of several human cancer cell lines with various p53, BRCA1 status, and their sensitivity to the combination treatment

Cell linePTENp53ARBRCA1Sensitivity to olaparib + BI2536
22RV-1Wild-typeMutantWild-typeNull++
PC3NullNullNullNull+
C4-2MutantWild-typeWild-typeWild-type
MDA-MB-231Wild-typeMutantWild-type++
  • “++” represents very sensitive to the combination treatment; “+” represents mildly sensitive; “−” represents no sensitivity.