Table 2.

Histopathologic and serologic analysis of tumor-bearing miR-122 KO mice treated with CCL2 nAb for 8 weeks

VehicleCCL2 nAbP
HCC incidence8/95/110.07
Tumor number2.67 ± 1.220.73 ± 0.790.0004
Sum of tumor diameter (cm)1.71 ± 1.240.57 ± 0.650.01
Serum ALT (U/L)151.89 ± 68.0673.57 ± 28.50.027
Serum AFP (IU/mL)14.07 ± 3.519.95 ± 0.610.001
  • NOTE: All measurements are presented as mean ± SD. P values were calculated using Student two-tailed t test (for tumor number, sum of tumor diameter, tumor weight, ALT, and AFP) or Fisher exact test (for hepatocellular carcinoma incidence).

  • Abbreviation: HCC, hepatocellular carcinoma.