EC50 valuesa (ng ADC/mL) for αCD30 conjugates bearing PEGx-glucuronide-MMAE linkers
| CD30+ Lymphoma cell lines | |||||
|---|---|---|---|---|---|
| ADC | PEGx | Karpas299, ALCL | L540cy, HL | L428, HL | Ramos, NHL (CD30−) |
| αCD30-4 | 24 | 0.3 ng/mL | 3 | 2 | >1,000 |
| αCD30-5 | 12 | 0.3 | 2 | 6 | >1,000 |
| αCD30-6 | 8 | 0.4 | 3 | 2 | >1,000 |
| αCD30-7 | 4 | 0.4 | 3 | 7 | >1,000 |
| αCD30-8 | 2 | 0.3 | 2 | 7 | >1,000 |
| αCD30-10 | – | 0.4 | 3 | 8 | >1,000 |
↵aEC50 is defined here as the concentration that achieves half-maximal growth inhibition over the titration curve.