Table 1.

EC50 valuesa (ng ADC/mL) for αCD30 conjugates bearing PEGx-glucuronide-MMAE linkers

CD30+ Lymphoma cell lines
ADCPEGxKarpas299, ALCLL540cy, HLL428, HLRamos, NHL (CD30)
αCD30-4240.3 ng/mL32>1,000
αCD30-5120.326>1,000
αCD30-680.432>1,000
αCD30-740.437>1,000
αCD30-820.327>1,000
αCD30-100.438>1,000
  • aEC50 is defined here as the concentration that achieves half-maximal growth inhibition over the titration curve.