Table 2.

Dosimetry and absorbed dose estimations for 70 kg Standard Man model calculated from the biodistribution data for 177Lu-DOTA-PEG7-Tz + 5B1-TCO in a murine xenograft model

Absorbed dose (rad) – 70 kg human
Organrad/mCiacGy/MBq150 mCi700 mCi
Adrenals0.2290.0061934160
Brain0.2220.0060033155
Breasts0.2150.0058132151
Gallbladder wall0.2310.0062435162
Lower long intestine wall0.2340.0063235164
Small intestine0.2820.0076242197
Stomach wall0.2350.0063535165
Upper long intestine wall0.2310.0062435162
Heart wall0.2630.0071139184
Kidneys0.1880.0050828132
Liver0.2290.0061934160
Lungs0.2230.0060333156
Muscle0.1560.0042223109
Ovaries0.2300.0062235161
Pancreas0.2300.0062235161
Red marrow0.2130.0057632149b
Osteogenic cells0.9820.02654147687
Skin0.2110.0057032148
Spleen0.1460.0039522102
Testes0.2200.0059533154
Thymus0.2230.0060333156
Thyroid0.2230.0060333156
Bladder wall0.2280.0061634160
Uterus0.2320.0062735162
Total body0.2800.0075742196
Effective dose0.2220.0060033155
  • aMean organ absorbed doses and effective dose are expressed in rad/mCi and rem/mCi.

  • bProjected dose-limiting organ for PRIT is bone marrow (MTD ∼ 150 rad).