Table 2.

EC50 valuesa (ng ADC/mL) for αCD19 conjugates bearing PEGx-glucuronide-MMAE linkers

CD19+ lymphoma cell lines
ADCPEGxRamos, NHLSU-DHL-4, DLBCLWSU-DLCL2, DLBCLRL, DLBCLL540cy, HL (CD19)
αCD19-4244 ng/mL10247>1,000
αCD19-512291722>1,000
αCD19-6831039160>1,000
αCD19-74315212>1,000
αCD19-82217714>1,000
αCD19-10213411>1,000
  • aEC50 is defined here as the concentration that achieves half-maximal growth inhibition over the titration curve.