EC50 valuesa (ng ADC/mL) for αCD19 conjugates bearing PEGx-glucuronide-MMAE linkers
| CD19+ lymphoma cell lines | ||||||
|---|---|---|---|---|---|---|
| ADC | PEGx | Ramos, NHL | SU-DHL-4, DLBCL | WSU-DLCL2, DLBCL | RL, DLBCL | L540cy, HL (CD19−) |
| αCD19-4 | 24 | 4 ng/mL | 10 | 2 | 47 | >1,000 |
| αCD19-5 | 12 | 2 | 9 | 17 | 22 | >1,000 |
| αCD19-6 | 8 | 3 | 10 | 39 | 160 | >1,000 |
| αCD19-7 | 4 | 3 | 15 | 2 | 12 | >1,000 |
| αCD19-8 | 2 | 2 | 17 | 7 | 14 | >1,000 |
| αCD19-10 | – | 2 | 13 | 4 | 11 | >1,000 |
↵aEC50 is defined here as the concentration that achieves half-maximal growth inhibition over the titration curve.