Table 1.

Combination index values for combination treatmentsa

CI at
Cell lineCombination treatment (ratio)IC50IC75IC90
BEL7404LAP + OSI (1:1)0.34760.60001.0459
SMMC7721LAP + OSI + JNJ (10:10:1)0.12300.02150.0039
WiDrLAP + OSI + JNJ (10:10:1)0.10050.10420.1129
DU145LAP + OSI + JNJ (10:10:1)0.29010.02790.0027
  • Abbreviations: CI, combination index; LAP, lapatinib.

  • aCombination index values for combination treatments were generated for the concentrations at which 50%, 75%, or 90% of the cell growth were inhibited (IC50, IC75, and IC90, respectively). CI < 0.9, synergy; 0.9 < CI < 1.1, additive.